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Botanical Reference Materials

Botanical Reference Materials (BRM™) are well characterized reference materials for specific plants.  ChromaDex™ offers a complete and growing product line of BRM™ to provide users with the tools necessary to better evaluate botanical raw materials.  The characterization of BRM™ may include macro and microscopic information for a specific genus and species of plant.  All BRM™ have a HP-TLC profile of the material.  Raw material identity from biomass to bottle is the main point of regulation in the cGMPs for dietary supplements.  BRM™ give users the tools necessary to know that their botanical raw material evaluation is comprehensive while affording them the opportunity to begin assessment of the material’s composition.  BRM™ are suitable for:

• Method validation
• Retention time marker
• System suitability
• Impurity profile
• Product development
• Laboratory control standard
• Qualitative standard
• Safety testing

BRM™ are categorized into six levels of product identity.

• Vouchered (VBRM™)
• Biomass (BRM™)
• Reagent Grade (RGBRM™)
• Representative (rBRM™)
• American Herbal Pharmacopoeia (AHP-BRM)
• Extract (XRM™)

Vouchered Botanical Reference Material
VBRM™ are highly characterized Botanical Reference Materials.  The Certificate of Analysis for ChromaDex™ VBRM™ includes macroscopic and micriscopic images with HP-TLC profiles.  In addition, a voucher is collected at the time of harvest and the plant is visually identified.  ChromaDex™ retains access to the full vouchered specimen that can be used for authenitication at a later date.  Upon request, an image of the voucher and/or at an additional cost full botanical authentication can be supplied.  Vouchered Botanical Reference Materials (VBRM™) are useful for:

• Raw material comparison
• Identity verification
• TLC/HPLC analysis
• Method development/validation
• Quality control of "in-house" or "working" reference material

Biomass Reference Material (BRM™)
BRM™ are well characterized Botanical Reference Materials.  The Certificate of Analysis for ChromaDex™ BRM™ includes both macroscopic and micriscopic images with HP-TLC profiles.  Although BRM™ do not have a corresponding voucher, they are a quality value choice and are suitable for:

• Raw material comparison
• Identity support
• TLC/HPLC analysis
• Method development/validation

Representative Botanical Reference Material (rBRM™)
ChromaDex™ is the exclusive supplier of rBRM™ manufactured by Phyto-Technologies, Inc.  rBRM™ are a mixture of biomass collections from different growing locations.  Since chemical markers in a given biomass may vary by growing location due to environmental conditions, harvesting and post collection treatment, rBRM™ area more representative Reference Material.  rBRM™ are suitable for:

• Raw material comparison
• Identity support
• TLC/HPLC analysis
• Method development/validation

Reagent Grade Biomass Reference Material (RGBRM™)
RGBRM™ are Botanical Reference Materials characterized only by HP-TLC profile analysis detailed on their Certificates of Analysis.  RGBRM™ are an economical value and are best used for the following applications:

• Basic research
• Early stage method development/validation

American Herbal Pharmacopoeia (AHP-BRM™)
All AHP grade Botanical Reference Materials are VBRMTM grade reference materials that have been independently verified by the American Herbal Pharmacopoeia and will bead the AHP Verified logo.  The Certificate of Analysis will also bear the AHP verified statement.

Extract Reference Material (XRM)
XRMsTM are dried, powdered extracts of Botanical Reference Materials from a specific plant biomass.  The Certificate of Analysis for ChromaDexTM XRMsTM includes HP-TLC profiles and quantitative HPLC/GC analysis of major chemical markers.  As the extraction process cannot be guaranteed, they are not a substitute for actual Botanical Reference Materials.  XRMsTM should be sued along with Reference Standards to provide robust analytical results and are suitable for:

• Proficiency samples to verify test methods
• Research
• Method development/validation
• TLC analysis but should not be used for botanic identity